Trechispora hondurensis was described in 2020 from Cusuco National Park, a tropical montane cloud forest in Honduras. It differs from its closest relatives, T. echinospora, T. farinacea, and T. regularis, based on both morphological and phylogenetic evidence.

Trechispora hondurensis was described in 2020 from Cusuco National Park, a tropical montane cloud forest in Honduras, and has not been recorded again in the country since. Additionally, five sequences assigned to the species hypothesis of T. hondurensis (SH0886555.10FU, 1% treshold) have been obtained from both eDNA and sporocarp projects. Notably, T. hondurensis has been reported only once or twice in each country: Cusuco National Park (Honduras), Reserva Los Cedros (Ecuador), coordinates 8.75340000, -82.23940000 (Panama), -24.6026, -47.8779 (Brazil), and Pernambuco (Brazil).

The species is known from two locations in Brazil, separated by more than 2,000 km, but it likely occurs at additional sites within the region. Although Cusuco National Park has been intensively sampled, it has only been recorded once, making it reasonable to consider the species rare.

Known from broadleaved tropical montane cloud forest and tropical moist lowland forest. Sampled at a large elevational range going from 34 m a.s.l. (Brazilian collections) to 1,572 m a.s.l. (Honduran collections), growing on decaying plant remnants (small twig fragments, leaf litter, and nut shells). All species within the genus Trechispora are presumed saprotrophs, decomposing a wide range of plant remnants (source).

Cusuco National Park, despite being located in a biodiversity Hotspot for conservation priorities (Myers et al. 2000), faces a range of environmental threats (Martin et al. 2021). Honduras possesses one of the worst rates globally for deforestation in protected areas (Hansen et al. 2020) and habitat loss in Cusuco National Park was estimated at >7% between 2000 and 2017, increasing towards the latter years, indicating that the threat is accelerating. Deforestation is mainly bad in North and West sections of the park. Deforestation and climate change form significant threats for for T. honduriensis as both lead to a decline in suitable habitat.

The species is not utilized.